Propionibacterium species (currently named as Cutibacterium sp): Prevention, diagnosis and treatment
The use of orthopedic implants has been increasing steadily in the last 50 years, but despite considerable technological advances including perioperative antimicrobial prophylaxis, implant-associated infections remain a serious complication. These infections are caused by bacteria in the biofilm on the implant surfaces.
Implant-associated infections such as periprosthetic joint infections or spinal implant-associated infections are a feared complication after orthopedic surgery. These infections are usually difficult to treat, because microorganisms persist in biofilms on the orthopedic implant surface. Therefore, it would be desirable to prevent these infections.
Cutibacterium spp. are bacteria which normally colonize the human skin but they can also cause invasive infections in presence of an implant such as shoulder or hip prosthetic joint infections (Achermann et al., CMR, 2015, Achermann et al. Clin Infect Dis 2018;66(1): 54-63).
An improved prevention or an early diagnosis is the main objective of this research area to reduce morbidity in implant-associated infections caused by Propionibacterium sp. (currently named as Cutibacterium sp).
Involved research people
Effects of photodynamic therapy on the human inguinal skin microbiome to improve antiseptic effect.
Role of rifampin in Cutibacterium sp. periprosthetic joint infection (PJI) – a multi-center study supported by the ESCMID.
supported by the European Society of Clinical Microbiology and Infectious Diseases
Skin antisepsis to reduce Cutibacterium avidum colonization as a risk factor for periprosthetic joint infections.
Swiss Life Jubiläumsstiftung
Prospective observational cohort study on periprosthetic joint infections at the Balgrist University Clinic
Clostridium difficile at the USZ: a quality control study
The role of Cutibacterium acnes infection in intervertebral disc inflammation (with K. Würtz).
CABMM start up
Our team is involved in several national and international research projects about prevention, diagnostic and treatment of orthopedic infections not listed above. Yvonne Achermann is a board member of the European study group of the implant-associated infections (ESGIAI), member of the "Expertengruppe Infektionen der Schweizerischen Gesellschaft für Orthopädie und Traumatologie", and Swiss Country Delegate of the European Bone and Joint Infection Society (EBJIS).