Propionibacterium species (currently named as Cutibacterium sp): Prevention, diagnosis and treatment
The use of orthopedic implants has been increasing steadily in the last 50 years, but despite considerable technological advances including perioperative antimicrobial prophylaxis, implant-associated infections remain a serious complication. These infections are caused by bacteria in the biofilm on the implant surfaces.
Implant-associated infections such as periprosthetic joint infections or spinal implant-associated infections are a feared complication after orthopedic surgery. These infections are usually difficult to treat, because microorganisms persist in biofilms on the orthopedic implant surface. Therefore, it would be desirable to prevent these infections.
Cutibacterium spp. are bacteria which normally colonize the human skin but they can also cause invasive infections in presence of an implant such as shoulder or hip prosthetic joint infections (Achermann et al., CMR, 2015, Achermann et al. Clin Infect Dis 2018;66(1): 54-63).
An improved prevention or an early diagnosis is the main objective of this research area to reduce morbidity in implant-associated infections caused by Propionibacterium sp. (currently named as Cutibacterium sp).
thesis student: Steven Maurer
- Medical master
student: Natalie Gassmann
2018 (submitted) Fabian Kalt (master thesis):
Corynebacterium species rarely cause orthopedic
und Betreuung Y. Achermann.
Fabienne Rüber (master thesis):
und Outcome Analyse von periprothetischen Gelenksinfektionen mit einem
zweizeitigen Wechsel der Prothese an der Schulthess Klinik in Zürich. Leitung
und Betreuung Y. Achermann.
2018 (submitted) Laura Stadler (master
Inflammatory disorders mimicking periprosthetic
joint infections may result in false-positive α-defensin. Leitung und
Betreuung Y. Achermann.
2018 Laura Böni (master thesis):
Cutibacterium avidum colonization in the groin is
associated with obesity. Leitung und Betreuung Y. Achermann.
Judith Glanzmann (master thesis):
Optimierung der Diagnostik bei Verdacht auf einen
Protheseninfekt. Leitung A. Zinkernagel. Betreuung: Y. Achermann.
2017 Daniel Bossard (doctoral thesis):
Optimal cultivation length to isolate Propioni
Clinical and microbiological study: Association
between clinical and microbiological characteristics and treatment outcome in
Cutibacterium sp. periprosthetic joint infection (PJI) – a multicenter study in
Europe (PI: Y. Achermann, Co-PI: J. Esteban, supported by the European Society
of Clinical Microbiology and Infectious Diseases)
Clinical and microbiological study: Optimal skin
antisepsis to reduce Cutibacterium avidum colonization as a risk factor for
periprosthetic joint infections (PI: Y. Achermann, Swiss Life Jubiläumsstiftung
funding CHF 20'000)
Basic Science: Pulsed electromagnetic field
stimulation: proof of concept in sheep model for microbial challenge (PI S.
Darwiche, Co-PI Y. Achermann, industry (DePuy Synthesis)-sponsored trial)
Clinical study: Retrospective Multicentre Study on
Characteristics of Deep Spinal Implant Infections in Adult Patients Treated
with Implant Retention (PI: T. Kramer, Local PI in Zurich: Y. Achermann,
supported by the European Society of Clinical Microbiology and Infectious
Clinical study: Prospective observational cohort
study on periprosthetic joint infections (PI: P. Zingg and Y. Achermann
Basic Science: The role of Propionibacterium acnes
infection in intervertebral disc inflammation (PI: K. Würtz and Y. Achermann,
CABMM start up grant CH 27'824)
- Prof. Andrew McDowell, Assistant Professor in Stratified Medicine
NI Centre for Stratified Medicine,
- Prof. Karin Wuertz-Kozak, R.Ph., Ph.D., MBA, Institute for
Biomechanics, ETH Zurich
- Prof. Reinhard
Zbinden, MD, Institut für medizinische Mikrobiologie, Zürich, Schweiz
- Prof. Annelies
Zinkernagel, MD Klinik für Infektionskrankheiten und Spitalhygiene,