Barbara Hasse

    

Project

VASGRA

The Vascular graft cohort study (VASGRA) is an ongoing single-center research project at the University hospital Zurich dealing with adults aged 18 years or older with an implanted vascular graft and/ or prosthetic vascular graft infection (PVGI). It was established in 2013. There is a clear separation between hospital infrastructure and research budget, implementation of a quality control programs and research by nested projects. VASGRA is supported by the Swiss National Science Foundation (SNF). Our research goals are:

Epidemiology
- Determine the incidence and outcome of complications after vascular graft placement
- Determine risk factors, best treatment strategies, and outcome of PVGI
- Determine the influence of different antibiotic regimens on outcome of PVGI due to different bacterial pathogens

Imaging techniques

- Determine accuracy of PET/CT in the assessment of treatment response in PVGI
- Determine accuracy of MRI, angio-CT and PET/CT for the diagnosis of PVGI

Microbiology

- Determine the bacterial diversity of vascular wounds using broad range PCR
- Determine the impact of negative pressure wound therapy on bacterial
diversity in PVGI using broad range PCR

Biomarkers
- Determine cut-off levels of blood leucocytes count, ESR, CRP and
procalcitonin raising suspicion of a PVGI

Histopathology
- Evaluate histopathological features of tissue and excised vascular grafts

Basic Research
- In a collaboration with the Laboratory of Prof Dr. A. Zinkernagel we will examine whether antibiotics interfering with protein synthesis affect bacterial biofilm formation.

Collaborators

  • Prof. Dr. Annelies Zinkernagel, Senior physician, Division of Infectious Diseases and Hospital Epidemiology, USZ
  • Dr. Lars Husmann, MD, Clinic for Nuclear Medicine USZ
  • PD Dr. Irene Burger, MD, Clinic for Nuclear Medicine USZ
    Dr. Ewerton Marques Maggio, MD, Institute of Molecular Pathology, USZ
  • PD Dr. Zoran Rancic, Attending physician, Clinic for cardiovascular surgery, USZ
  • Prof. Dr. Mario Lachat, Leiter Gefässchirurgie, cardiovascular surgery, USZ
  • PD Dr. Dieter Mayer, MD senior attending physician, Cantonal Hospital Fribourg, Chemin des Pensionnats 2, 1708 Fribourg
Publications
Contact

Division of Infectious Diseases and Hospital Epidemiology
Barbara Hasse; MD
University hospital Zurich
Raemistrasse 100
8091 Zurich

Phone.+41 44 255 92 37
Fax +41 44 255 44 99