To circumvent the human immune system, pathogens express a wide array of virulence factors. A better understanding of how these virulence factors work, how they are influenced by the environment as well as whether the presence of antibiotics modulates their activity and expression, is of great importance to fine-tune the therapy against bacterial infections in the best possible way. In particular considering the worldwide increase in antibiotic resistant bacteria, both Gram-positive (e.g.
Staphylococci) as well as Gram-negative (e.g.
Pseudomonas), requires the establishment of new treatment.
Relapse rates of
Staphylococcus aureus infections are high despite
in vitro effective antibiotic treatment. The ability of
Staphylococcus aureus to persist within host cells protects bacteria from the host immune system as well as from extracellular active antibiotics. Aiming to reduce relapse rates we are investigating the underlying mechanism of bacterial persistence and aim to optimize current treatment strategies.
Many chronic infections are caused by the presence of a bacterial biofilm. A biofilm is an agglomerate of microorgansims, which can attach to biotic or abiotic surfaces and to each other, and are embedded in a matrix. The matrix enables the microorganisms to protect themselves from both the immune system and from the action of antibiotics. We are studying microorganisms sampled directly from biofilms by looking at their pathogenicity and behavior in various milieux, thereby searching for better diagnosis and treatment options for biofilm infections.
All our projects are supported through interdisciplinary collaborations with other laboratories. We are collaborating with other hospitals as well as research groups at the University of Zurich and ETH Zurich. In addition we have collaborations with research groups in Germany, France and the USA.
MD PhD and PhD students
Biology master students